The reality TV star and make-up mogul announced the news with a 90-second Instagram video featuring the moment she discovered she was pregnant.
The video opens with the 24-year-old carrying a positive pregnancy test around her California home before showing it to Scott, 30.
The Houston-born rapper is then seen hugging her belly and in the next scene Jenner and Scott’s three-year-old daughter Stormi accompanies them for an early ultrasound.
The footage also captures the moment she told her mother, Kris Jenner, 65, although no other members of the Jenner-Kardashian family are seen.
“Are you pregnant?” the family matriarch asks. “Stormi, we’re gonna have a baby! This is one of the happiest days of my life.”
The video ends with Stormi kissing her mother’s growing bump.
Jenner and Scott, a chart-topping musician whose songs include Highest In The Room and Sicko Mode, first started dating in 2017, with Stormi arriving the following year.
They reportedly split in 2019 but were said to have got back together earlier this year.